Cholesterol homeostasis什么意思
WebCholesterol homeostasis is a highly regulated process in human body because of its several functions underlying the biology of cell membranes, the synthesis of all steroid … Webhomeostasis翻译：体内动态平衡（机体、活细胞、组织等，在其外部环境变化的情况下，保持内部不变或平衡状态的能力或趋向 ...
Cholesterol homeostasis什么意思
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WebAug 24, 2024 · Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nature Communications, 2024; 12 … WebDec 17, 2024 · Cholesterol homeostasis at systemic levels requires collaboration between various tissues, which ensures a balance between cholesterol absorption (in the intestine) and cholesterol biosynthesis ...
WebJan 7, 2024 · Cholesterol is an indispensable component of the cell membrane and plays vital roles in critical physiological processes. Brain cholesterol accounts for a large portion of total cholesterol in the human body, and its content must be tightly regulated to ensure normal brain function. Disorders of cholesterol metabolism in the brain are linked to … Web胆固醇 （cholesterol ）是哺乳动物体内含量最丰富的甾醇类分子，是细胞膜的基本组分之一，能与邻近脂类分子作用调节膜的刚性、流动性和渗透性，或与跨膜蛋白结合维持或改变后者的构象。. 胆固醇也是氧化甾醇和甾 …
WebMar 15, 2024 · 3. Regulation of Cholesterol Homeostasis. In humans, only about a third of the body cholesterol is of dietary origin (mainly eggs and red meat), the remainder is produced by synthesis de novo in the endoplasmic reticulum. Because cholesterol cannot be catabolized for energy purposes (see below), its synthesis must be tightly regulated … WebAug 30, 2024 · As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among which, the …
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WebMar 9, 2024 · Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficking from late endosomes and lysosomes to the endoplasmic reticulum. We identified NPC1 … maytag collectorsWebJul 7, 2024 · Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is obtained from the diet or can be de novo synthetized. Cholesterol homeostasis is mainly regulated by the liver, wh … maytag cold water not workingWebJan 25, 2016 · Data demonstrating ERS-induced apoptosis in cancer cells submitted to complex lipid and/or cholesterol homeostasis alterations open a promising therapeutic window. It allows us to predict that ... maytag collectors websiteWebCholesterol Homeostasis. Cholesterol metabolism in mammals involves multiple organs (see Fig. 20.15 for the synthetic pathway). Approximately 90% of the free cholesterol in animal cells is in the plasma membrane. Cholesterol is the precursor for steroid hormones, which are synthesized in specialized cells but used throughout the body for myriad ... maytag cold wash cycleWebMar 15, 2013 · Recently, cholesterol homeostasis has been shown to be restored by LBH589 (panobinostat), an anticancer drug, in NPC1 mutant fibroblasts to normal levels. … maytag commercial actors nameWebSep 22, 2014 · MicroRNA-223 (miR-223) transcription and expression are maintained by cholesterol, and, as a feedback network, miR-223 inhibits cholesterol biosynthesis and uptake and increases cholesterol efflux. This study clearly demonstrates the extensive role that miRNAs play in coordinating metabolic adaptation to disease and general … maytag combo sets refrig and freezerWebAug 24, 2024 · The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. … maytag combo washer dryer electric 2005