WebFeb 25, 2024 · In a recent issue of Protein Science, Lazar et al. published an article entitled “Intrinsic protein disorder uncouples affinity from binding specificity” (Lazar et al., … WebApr 10, 2024 · Advances in structural biology have provided important mechanistic insights into signaling by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is known about intrinsically disordered regions such as the carboxyl terminus (CT), which is highly flexible and not visible in GPCR structures.
Function and dynamics of the intrinsically disordered carboxyl …
WebAug 3, 2024 · Intrinsically disordered proteins. The regulatory elements of transcription factors (TFs), initially recognized as acid blobs, were among the earliest disordered regions with a clear link to their functional roles [1]. TFs have intrinsically disordered protein regions (IDRs) often within structured DNA-binding domains (DBDs). WebAug 4, 2024 · A protein’s structure is determined by its amino acid sequence and post-translational modifications, and provides the basis for its physiological functions. Across all organisms, roughly a third of the proteome comprises proteins that contain highly unstructured or intrinsically disordered regions. Proteins comprising or containing … leaderboard systems.com
Intrinsically disordered proteins: modes of binding with …
WebJan 9, 2013 · Coupled folding and binding of intrinsically disordered proteins (IDPs) is prevalent in biology. As the first step toward understanding the mechanism of binding, it … Web2. Anatomy of an intrinsically disordered protein Most proteins consist of a densely packed hydrophobic core and exist as a minimum free energy native fold. Towards the N … WebNov 25, 2024 · Proteins containing intrinsically disordered regions are present in a considerable fraction of the proteome of eukaryotic organisms (e.g. 43.6% in humans based on MobiDB-lite predictions). In the human proteome, for example, IDRs are highly enriched in interaction interfaces and post-translational modification sites, which serve as … leaderboard synonym